The β-Amyloid precursor protein (β-APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The β-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the β-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β-APP and slowing β-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β-APP. Multiple splice varitents of X11 have been identified, including X11α (also designated Mint 1), X11β (Mint 2) and X11γ (Mint 3).
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps X11γ (D-3) | sc-376926 | 200 µg/ml | $316.00 | |||
X11γ (D-3): m-IgG Fc BP-HRP Kit | sc-538012 | 200 µg Ab; 10 µg BP | $354.00 | |||
X11γ (D-3): m-IgGκ BP-HRP Kit | sc-535528 | 200 µg Ab; 40 µg BP | $354.00 |