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WAVE-associated Rac GTPase-activating protein (WRP), also known as SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) and Mental disorder-activating GAP (MEGAP), is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps WRP (B-3) | sc-514179 | 200 µg/ml | $316.00 | |||
WRP (B-3): m-IgGκ BP-HRP Kit | sc-536244 | 200 µg Ab; 40 µg BP | $354.00 | |||
WRP (B-3): m-IgG2b BP-HRP Kit | sc-549528 | 200 µg Ab; 10 µg BP | $354.00 | |||
WRP (B-3) peptide neutralisant | sc-514179 P | 100 µg/0.5 ml | $68.00 |