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The Wnt family of protooncogenes consists of at least 13 known members which encode secreted signaling proteins that are involved in oncogenesis and several other developmental processes, such as regulation of cell fate and embryogenesis. Wnt-10a (wingless-type MMTV integration site family, member 10A) is a 417 amino acid protein that is secreted into the extracellular matrix and belongs to the Wnt family. Strongly expressed in promyelocytic leukemia and Burkitt's lymphoma, Wnt-10a functions as a ligand for frizzled proteins and is thought to be involved in development of the central nervous system, probably acting as a signaling molecule. Overexpression of Wnt-10a is associated with the pathogenesis of various carcinomas, strongly suggesting a role for Wnt-10a in tumor development and metastasis. Defects in the gene encoding Wnt-10a are the cause of odonto-onycho-dermal dysplasia (OODD), a rare autosomal recessive disorder that is characterized by dry hair, onychodysplasia and hyperkeratosis of the skin.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Wnt-10a (C-9) | sc-376029 | 200 µg/ml | $316.00 | |||
Wnt-10a (C-9): m-IgG Fc BP-HRP Kit | sc-540498 | 200 µg Ab; 10 µg BP | $354.00 | |||
Wnt-10a (C-9): m-IgG1 BP-HRP Kit | sc-542161 | 200 µg Ab; 20 µg BP | $354.00 |