Date published: 2025-9-8

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Anticorps WIP (A-7): sc-271113

5.0(3)
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Fiches techniques
  • L'Anticorps WIP (A-7) est un monoclonal de souris IgG2b κ, cité dans 5 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 178-205 près de C-terminus de WIP d'origine human
  • recommandé pour la détection de WIP d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
  • m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps WIP (A-7) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps WIP (A-7) (voir Informations pour la commande ci-dessous).

ACCÈS RAPIDE AUX LIENS

VOIR ÉGALEMENT...

Mutations in the Wiskott-Aldrich syndrome protein (WASP) often result in immunodeficiency due to abnormal T cell and B cell activation. The 503 amino acid WAS-interacting protein (WIP) contains a number of domains implicated in actin-binding and several putative src homology-binding domains. The first 100 amino acids of WASP interact with amino acids 377-503 of WIP (3,4), and the majority of pathogenic mutations associated with WAS occur within the first 100 amino acids of WASP. The gene encoding human WIP maps to chromosome 2p23.3-q24.3. Overexpression of WIP in the human B cell line BJAB increases F-actin content and cerebriform projections. While both WIP and Vav cooperate in the regulation of NF-AT/AP-1 gene transcription, the WIP-WASP complex is required for activation of NF-AT/AP-1 necessary for proper T cell function. A dysfunctional WIP-WASP complex may be implicated in the immunodeficient phenotype in WAS.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps WIP (A-7)

sc-271113
200 µg/ml
$316.00

WIP (A-7): m-IgGκ BP-HRP Kit

sc-534872
200 µg Ab; 40 µg BP
$354.00

WIP (A-7): m-IgG2b BP-HRP Kit

sc-549309
200 µg Ab; 10 µg BP
$354.00

WIP (A-7) peptide neutralisant

sc-271113 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-271113 P appropriate for?

Posée par: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Répondue par: Technical Support
Date de publication: 2017-02-24
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Rated 5 de 5 de par Excellent!I got this primary antibody one week ago, WIP expression in H460 and H358 whole cell lysate at 1:500 dilution.I got a sepcific and beautiful band.
Date de publication: 2017-11-03
Rated 5 de 5 de par Works well for WB with human WIP transfectedWorks well for WB with human WIP transfected 293T whole cell lysate. -SCBT QC
Date de publication: 2015-05-24
Rated 5 de 5 de par Beautiful immunoperoxidase cytoplasmic stainingBeautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date de publication: 2015-01-08
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Anticorps WIP (A-7) est évalué 5.0 de 5 de 3.
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