VDUP1 Antibody (H-12): sc-271238

VDUP1 Antibody (H-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects VDUP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VDUP1 (H-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The vitamin D3 upregulated protein 1 (VDUP1) plays a crucial role in cellular stress responses, being upregulated by 1,25(OH)2D3 in reaction to oxidative stress, ultraviolet radiation, and heat shock, with the transcription factor heat shock factor potentially mediating this regulation. VDUP1 acts as a natural antagonist of thioredoxin (TRX), contributing to tumor-suppressive properties by inducing cell cycle arrest at the G0/G1 phase, which is vital for preventing uncontrolled cell proliferation. VDUP1 is essential for the expression of CD122 and the maturation of natural killer (NK) cells, although VDUP1 influence on T and B cell development is relatively minor. The gene encoding human VDUP1 is located on chromosome 1q21, and VDUP1 is ubiquitously expressed across various tissues, predominantly localizing to the cytoplasm. Given VDUP1 significant roles in immune regulation and potential implications in cancer therapy, particularly for melanoma, VDUP1 represents a promising target for further research and therapeutic development.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VDUP1 Antibody (H-12) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-VDUP1 Antibody (H-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VDUP1 Antibody (H-12) Specifications

Alternate Product Name: VDUP1

Product Clone Name: H-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 323-356

Epitope Target: VDUP1

Epitope Species: human

Product Reactivity/Detection: VDUP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for VDUP1 Antibody (H-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred VDUP1 antibody is VDUP1 Antibody (B-2): sc-166234.