Vatalanib Dihydrochloride CAS: 212141-51-0
MF: C20H15ClN4•2HCl
MW: 419.73
A potent inhibitor of EGFR- and RET-dependent tumor cell proliferation and survival.

Vatalanib Dihydrochloride (CAS 212141-51-0)

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Vatalanib Dihydrochloride is rated 5.0 out of 5 by 1.
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Noms alternatifs: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Application: Vatalanib Dihydrochloride is a potent inhibitor of EGFR- and RET-dependent tumor cell proliferation and survival
Numéro CAS: 212141-51-0
Pureté: ≥96%
Masse Moléculaire: 419.73
Formule Moléculaire: C20H15ClN42HCl
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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Vandetanib Dihydrochloride inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. Vatalanib Dihydrochloride also inhibits Flk, c-Kit and PDGFR-β with IC50 of 270 nM, 730 nM and 580 nM, respectively. Furthermore, Vatalanib Dihydrochloride shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs


Références

1. Herbst, R.S., et al. 2007. Expert Opin. Investig. Drugs. 16: 239-249. PMID: 17243944

État Physique :
Solid
Solubilité :
Soluble in DMSO (30 mg/mL), ethanol (10 mg/mL) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/mL ).
STOCKAGE :
Store at -20° C
Point de fusion :
244-246° C
IC50 :
VEGF receptor/KDR: IC50 = 37 nM; VEGF receptor/Flt-1: IC50 = 77 nM; VEGF receptor/Flk: IC50 = 270 nM; c-Kit: IC50 = 730 nM; PDGFR-β: IC50 = 580 nM; VEGF-induced phosphorylation: IC50 = 17 nM (HUVEC50s cells); VEGF-induced phosphorylation: IC50 = 34 nM (CHO cells); Thymidine incorporation induced by VEGF: IC50 = 1.7 nM (HUVEC50s)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
PubChem CID :
SMILES :
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

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