v-SNARE Vti1a Antibody (45): sc-136117

v-SNARE Vti1a Antibody (45) is a mouse monoclonal IgG1 kappa light chain antibody that detects v-SNARE Vti1a of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-v-SNARE Vti1a antibody (45) is available as a non-conjugated format. v-SNARE Vti1a, also known as vesicle transport v-SNARE protein Vti1-like 2, plays a crucial role in vesicular transport, essential for eukaryotic cell survival. v-SNARE Vti1a participates in SNARE complex formation, interacting with various t-SNARE proteins, including syntaxin 7, syntaxin 8, and syntaxin 10, to facilitate vesicle fusion with target membranes. Proper functioning of v-SNARE Vti1a is vital for trafficking important proteins such as Glut4, which enables glucose uptake in adipocytes. v-SNARE Vti1a and Glut4 levels decrease following insulin treatment, and v-SNARE Vti1a mRNA knockdown inhibits adiponectin secretion and insulin-stimulated deoxyglucose uptake, indicating a significant regulatory role in metabolic processes.

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v-SNARE Vti1a Antibody (45) References:

1. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners.  |  Kreykenbohm, V., et al. 2002. Eur J Cell Biol. 81: 273-80. PMID: 12067063
2. Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum.  |  Bogdanovic, A., et al. 2002. Biochem J. 368: 29-39. PMID: 12175335
3. The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes.  |  Bose, A., et al. 2005. J Biol Chem. 280: 36946-51. PMID: 16131485
4. SNAREs in neurons--beyond synaptic vesicle exocytosis (Review).  |  Wang, Y. and Tang, BL. 2006. Mol Membr Biol. 23: 377-84. PMID: 17060155
5. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells.  |  Ganley, IG., et al. 2008. J Cell Biol. 180: 159-72. PMID: 18195106
6. A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels.  |  Flowerdew, SE. and Burgoyne, RD. 2009. Biochem J. 418: 529-40. PMID: 19138172
7. Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking.  |  Bethani, I., et al. 2009. Traffic. 10: 1543-59. PMID: 19624487
8. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways.  |  Fischer von Mollard, G. and Stevens, TH. 1998. J Biol Chem. 273: 2624-30. PMID: 9446565

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-v-SNARE Vti1a Antibody (45) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-v-SNARE Vti1a Antibody (45) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

v-SNARE Vti1a Antibody (45) Specifications

Alternate Product Name: v-SNARE Vti1a

Product Clone Name: 45

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 114-217

Epitope Target: v-SNARE Vti1a

Epitope Species: mouse

Product Reactivity/Detection: v-SNARE Vti1a

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for v-SNARE Vti1a Antibody (45): N/A