Anticorps UPIIIa (F-11): sc-166598
- L'Anticorps UPIIIa (F-11) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 21-200 situés près de la région N-terminus de UPIIIa d'origine human
- recommandé pour la détection de UPIIIa d'origine mouse, rat et human par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP est le réactif de détection secondaire préféré pour l'anticorps UPIIIa (F-11) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps UPIIIa (F-11)(voir les informations relatives à la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps UPIIIa (F-11) | sc-166598 | 200 µg/ml | $316.00 | |||
UPIIIa (F-11): m-IgG2b BP-HRP Kit | sc-548523 | 200 µg Ab; 10 µg BP | $354.00 |