Unc18-1, -2 and -3 (syntaxin binding proteins 1-3, STXBP1-3, UNC18-a-c, MUNC18-1-3) are chaperone molecules that block syntaxin interactions with cognate SNARE (soluble NSF attachment protein (SNAP) receptors) proteins and regulate exocytosis. Unc18-1-3 mRNA is present in RBL-2H3 mast cells, mouse bone marrow derived mast cells (BMMC) and platelets. Unc18-1 Ser 313 is a protein kinase C phosphorylation site and Thr 574 is a cyclin-dependent kinase 5 phosphorylation site that regulates Unc18-1/syntaxin1A interactions. Unc18-1 is phosphorylated on Ser 313 in response to phorbol ester treatment in adrenal chromaffin cells. Unc18-2 co-localizes with Syntaxin 3 at the apical plasma membrane of intestinal, proximal tubule and collecting duct epithelial cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Unc18-2 (A-6) | sc-390503 | 200 µg/ml | $316.00 | |||
Unc18-2 (A-6): m-IgG Fc BP-HRP Kit | sc-538085 | 200 µg Ab; 10 µg BP | $354.00 | |||
Unc18-2 (A-6): m-IgGκ BP-HRP Kit | sc-535622 | 200 µg Ab; 40 µg BP | $354.00 | |||
Unc18-2 (A-6): m-IgG1 BP-HRP Kit | sc-545515 | 200 µg Ab; 20 µg BP | $354.00 |