Anticorps UBE2G1 (G-832): sc-100619
- L'Anticorps UBE2G1 (G-832) est un monoclonal de souris IgG1 κ, cité dans 1 publications, fourni en 100 µg/ml
- dirigé contre la UBE2G1 recombinante d'origine human
- recommandé pour la détection de UBE2G1 d'origine mouse, rat et human par WB, IP, IF et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire UBE2G1 (G-832). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53% homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12 in order to conjugate to substrates directed to different proteolytic systems. Ubc4 catalyzes ubiquitination of IκBα in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component Ubc4, and Ubc4 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IκBα for degradation by a proteasome thus lifting the inhibitory effect of IκBα on NFκB and allowing NFκB to enter the nucleus.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps UBE2G1 (G-832) | sc-100619 | 100 µg/ml | $333.00 |