Date published: 2025-9-9

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Anticorps Twinfilin-1 (C-12): sc-376418

5.0(2)
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Fiches techniques
  • L'Anticorps Twinfilin-1 (C-12) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
  • dirigé contre les acides aminés 175-236 situés près de la région C-terminus de Twinfilin-1 d'origine human
  • recommandé pour la détection de Twinfilin-1 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
  • m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps Twinfilin-1 (C-12) pour les applications WB et IHC(P). Ces réactifs sont désormais proposés en lots avec l'anticorps Twinfilin-1 (C-12)(voir les informations de commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    Twinfilin is a highly conserved Actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals. Twinfilin is composed of two ADF-homology domains; it coordinates filament severing and monomer sequestering at sites of rapid Actin turnover, thus preventing assembly of the monomer into filaments. Twinfilin-1 is the mammalian homolog and is expressed in embryos and in most adult non-muscle cell types. Twinfilin-1 binds ADP-G-Actin and efficiently halts Actin filament assembly by inhibiting the nucleotide exchange on Actin monomers and directly interacting with the capping protein. Phosphatidylinositol (4,5)-bisphosphate inhibits the activity of Twinfilin-1, while two small GTPases, namely Rac1 and Cdc42, induce the redistribution of Twinfilin-1 to membrane ruffles and cell-cell contacts, respectively.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps Twinfilin-1 (C-12)

    sc-376418
    200 µg/ml
    $316.00

    Twinfilin-1 (C-12): m-IgG Fc BP-HRP Kit

    sc-537984
    200 µg Ab; 10 µg BP
    $354.00

    Twinfilin-1 (C-12): m-IgGκ BP-HRP Kit

    sc-535486
    200 µg Ab; 40 µg BP
    $354.00

    Twinfilin-1 (C-12): m-IgG1 BP-HRP Kit

    sc-545475
    200 µg Ab; 20 µg BP
    $354.00

    Can Twinfilin-1 (C-12): sc-376418 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Posée par: Randy McDonald
    Thank you for your question. Yes, Twinfilin-1 (C-12): sc-376418 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Répondue par: Technical Support
    Date de publication: 2017-03-01
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    Rated 5 de 5 de par Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human colon tissue. -SCBT QC
    Date de publication: 2015-05-06
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    Anticorps Twinfilin-1 (C-12) est évalué 5.0 de 5 de 2.
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