The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC4 (tetratricopeptide repeat domain 4) is a 387 amino acid ubiquitously expressed nucleoplasmic protein containing three TPR repeats. TTC4 localizes to the cytoplasm, however, when paired with MSL-1, TTC4 translocates to the nucleus during the G1 and S phases of the cell cycle. TTC4 interacts with HSP 90, HSP 70 and with the replication protein Cdc6 and may be associated with the progression of malignant melanoma. The gene encoding TTC4 is located on human chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TTC4 (TR-L6) | sc-135591 | 100 µg/ml | $333.00 |