Anticorps TRP1 (4D25): sc-73239
- L'Anticorps TRP1 (4D25) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
- élevé contre la lignée cellulaire de mélanome SK-MEL-23 d'origine human.
- recommandé pour la détection de TRP1 in melanomas d'origine mouse, rat et human par WB et IF; non cross-reactif avec carcinomas and sarcomas
- Voir TRP1 (G-9): sc-166857 pour d'autres anticorps conjugués TRP1, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG Fc BP-HRP et 2a BP-HRP">m-IgG2a BP-HRP sont les réactifs de détection secondaire préférés pour TRP1 Antibody (4D25) pour les applications WB. Ces réactifs sont désormais proposés en lots avec TRP1 Antibody (4D25)(voir les informations de commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
Tyrosinase (TYR), a type I membrane protein and copper-containing enzyme, is involved in the production of melanin, the primary pigment found in vertebrates. Melanin biogenesis requires the enzymatic activity of TYR, which catalyzes the critical and rate-limiting step of tyrosine hydroxylation in the biosynthesis of melanin. Defects effecting TYR activity result in various forms of albinism. The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteine-rich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exists as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TRP1 (4D25) | sc-73239 | 200 µg/ml | $316.00 | |||
TRP1 (4D25): m-IgG Fc BP-HRP Kit | sc-539463 | 200 µg Ab; 10 µg BP | $354.00 | |||
TRP1 (4D25): m-IgG2a BP-HRP Kit | sc-546708 | 200 µg Ab; 10 µg BP | $354.00 |