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Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind Actin filaments and function to modulate Actin-Myosin interaction and stabilize Actin filament structure. Tropomyosin α is encoded by the TPM1 gene, which maps to human chromosome 15q22.1 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin β is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with Actin filaments may increase the rigidity of Actin filaments. Tropomyosin also interacts with Caldesmon to regulate smooth muscle contraction.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Tropomyosin (C-3) | sc-376339 | 200 µg/ml | $316.00 | |||
Tropomyosin (C-3): m-IgG Fc BP-HRP Kit | sc-540549 | 200 µg Ab; 10 µg BP | $354.00 | |||
Tropomyosin (C-3): m-IgG1 BP-HRP Kit | sc-542198 | 200 µg Ab; 20 µg BP | $354.00 | |||
Tropomyosin (C-3) peptide neutralisant | sc-376339 P | 100 µg/0.5 ml | $68.00 |