The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM16 (tripartite motif-containing 16), also known as EBBP (Estrogen-responsive B box protein), is a 564 amino acid protein that belongs to the TRIM family and contains two B box-type zinc fingers and one B30.2/SPRY domain. TRIM16 is highly expressed in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. However, it is more highly expressed in fetus than in the corresponding adult tissues. TRIM16 is also expressed in basal keratinocytes, where it is thought to play a role in the regulation of keratinocyte differentiation. Overexpression of TRIM16 has been shown to increase histone acetylation in retinoid-resistant cancer cells and therefore may be a potential target for therapeutic drugs.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TRIM16 (5-RY8) | sc-135586 | 100 µg/ml | $333.00 |