Date published: 2026-10-17

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Anticorps transferrin (E-8): sc-393595

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Fiches techniques
  • L'Anticorps transferrin (E-8) est un monoclonal de souris IgG1 κ, cité dans 6 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 573-582 près de C-terminus de transferrin d'origine human
  • recommandé pour la détection de transferrin d'origine human par WB, IP, IF, IHC(P) et ELISA
  • Voir transferrin (D-9): sc-365871 pour d'autres anticorps conjugués transferrin, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps transferrin (E-8) pour les applications WB et IHC(P). Ces réactifs sont désormais proposés en lots avec l'anticorps transferrin (E-8)(voir les informations de commande ci-dessous).
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Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA

LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences

Anticorps transferrin (E-8) Références:

  1. Microhétérogénéité de la transferrine dans la périlymphe humaine.  |  Rauch, SD. 2000. Laryngoscope. 110: 545-52. PMID: 10763998
  2. Erythropoïétine et métabolisme de la transferrine dans le syndrome néphrotique.  |  Vaziri, ND. 2001. Am J Kidney Dis. 38: 1-8. PMID: 11431174
  3. Régulation de l'expression du gène de la transferrine.  |  Zakin, MM. 1992. FASEB J. 6: 3253-8. PMID: 1426763
  4. Saturation en transferrine et mortalité.  |  Benyamin, B., et al. 2011. Clin Chem. 57: 921-3; author reply 923. PMID: 21343418
  5. Changements de la transferrine chez les patients hémodialysés.  |  Formanowicz, D. and Formanowicz, P. 2012. Int Urol Nephrol. 44: 907-19. PMID: 21455763
  6. Délivrance d'acides nucléiques thérapeutiques via la transferrine et les récepteurs de la transferrine: lipoplexes et autres transporteurs.  |  Tros de Ilarduya, C. and Düzgüneş, N. 2013. Expert Opin Drug Deliv. 10: 1583-91. PMID: 24050263
  7. Mesure de l'absorption du fer lié ou non à la transferrine par les tissus de souris.  |  Jenkitkasemwong, S., et al. 2016. Bio Protoc. 6: PMID: 28573162
  8. Association des polymorphismes de la transferrine G258A et du récepteur de la transferrine A82G avec le risque de maladie de Parkinson dans certaines régions.  |  Wang, Y., et al. 2020. Medicine (Baltimore). 99: e23432. PMID: 33235126
  9. Transferrine et échanges cellulaires de fer.  |  Young, S. and Bomford, A. 1984. Clin Sci (Lond). 67: 273-8. PMID: 6088154
  10. Comparaison des séquences de transferrine de différentes espèces.  |  Baldwin, GS. 1993. Comp Biochem Physiol B. 106: 203-18. PMID: 8403849

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps transferrin (E-8)

sc-393595
200 µg/ml
$322.00

transferrin (E-8): m-IgG Fc BP-HRP Kit

sc-538254
200 µg Ab; 10 µg BP
$361.00

transferrin (E-8): m-IgGκ BP-HRP Kit

sc-535831
200 µg Ab; 40 µg BP
$361.00

transferrin (E-8): m-IgG1 BP-HRP Kit

sc-545601
200 µg Ab; 20 µg BP
$361.00

transferrin (E-8) peptide neutralisant

sc-393595 P
100 µg/0.5 ml
$69.00

We have been looking for antibodies which recognize human transferrin, but not mouse or bovine transferrin. Do you have those antibodies?

Posée par: Kenjiyum
Thank you for your question. We currently offer two different monoclonal antibodies which are recommended for detection of human transferrin alone. One is our, transferrin (D-9): sc-365871, and the other is our transferrin (E-8): sc-393595. We have not specifically tested these antibodies for lack of cross-reactivity with mouse or bovine transferrin. Please contact our Technical Service Department and we would be happy to perform sequence analysis on the antibody immunogen sequences and provide you with more information about potential cross-reactivity with these other species. Please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website. For a limited time, we are offering a free sample of one of these mouse monoclonal antibodies, sc-365871: transferrin (D-9). Please contact our Technical Service Department if you would like to request a free sampe to test.
Répondue par: Technical Support
Date de publication: 2017-05-19

Can I use transferrin (E-8): sc-393595 monoclonal antibody for detection of mouse protein?

Posée par: cjMara
We do not currently recommend the (E-8) clone for use in mouse samples (it has not yet been tested). As an alternative, we would recommend either, transferrin (F-8): sc-373785, or transferrin (11D3): sc-52256, which have both been validated for use in mouse.
Répondue par: Technical Support
Date de publication: 2017-01-30
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Rated 5 de 5 de taks par Good for WBNice Western Blot data to detect transferrin uptake in human cancer cell line.
Date de publication: 2021-07-20
Rated 5 de 5 de Germaine par Highly recommended for IHC(P) and WB.Produced great Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes. Strong WB banding in human liver and human brain tissue extracts and Hep G2 whole cell lysate.
Date de publication: 2017-01-12
Rated 5 de 5 de SM par Very good Western blot data of transferrinVery good Western blot data of transferrin expression in Hep G2 whole cell lysate, transferrin in human plasma and human kidney tissue extract . -SCBT QC
Date de publication: 2014-01-30
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Anticorps transferrin (E-8) est évalué 5.0 de 5 de 3.
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