ACCÈS RAPIDE AUX LIENS
Human transformer-2 alpha (Tra-2α) and Tra-2β are nuclear proteins that associate with distinct pre-mRNA splicing enhancer elements. Tra-2α is the functional homolog of the Drosophila TRA-2 protein, which regulates the female specific pre-mRNA splicing pattern of the doublesex (dsx) gene in Drosophila. Human Tra-2 proteins are able to actively splice Drosophila sex factors; however, human Tra-2α has not been shown to induce sexual differentiation suggesting that human Tra-2α may regulate splicing patterns involving alternative mechanisms. Tra-2α and Tra-2β contain a single RNP-type RNA-binding domain and selectively bind to purine-rich sequences to facilitate mRNA splicing. Expression of Tra-2β is upregulated during the reoxygenation of hypoxic astrocytes. Tra-2α and Tra-2β interact with the serine/arginine-rich (SR) family of splicing factors to form Tra-2/SR complexes that then regulate tissue-specific alternative splicing patterns of many pre-mRNAs.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Tra-2β (D-4) | sc-166769 | 200 µg/ml | $316.00 | |||
Tra-2β (D-4): m-IgG Fc BP-HRP Kit | sc-540156 | 200 µg Ab; 10 µg BP | $354.00 | |||
Tra-2β (D-4): m-IgG1 BP-HRP Kit | sc-541937 | 200 µg Ab; 20 µg BP | $354.00 | |||
Tra-2β (D-4) peptide neutralisant | sc-166769 P | 100 µg/0.5 ml | $68.00 | |||
Anticorps Tra-2β (D-4) X | sc-166769 X | 200 µg/0.1 ml | $316.00 |