Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor 2, also designated Prothrombin or Factor 2, is proteolytically cleaved to form Thrombin in the first step of the coagulation cascade. Thrombin is a serine protease that influences cellular mitogenesis, tumor growth and metastasis, and can initiate platelet aggregation and secretion. Thrombin also influences vascular integrity during development and postnatal life. During the mechanism of wound healing, Thrombin may coordinate connective tissue proteins by stimulating fibroblast procollagen production.
Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.
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Anticorps Thrombin (GMA-020) Références:
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