Thielavin B CAS: 71950-67-9
MF: C31H34O10
MW: 566.6
An inhibitor peptidoglycan formation, prostaglandin biosynthesis, and PLC.

Thielavin B (CAS 71950-67-9)

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Application: Thielavin B is an inhibitor peptidoglycan formation, prostaglandin biosynthesis, and PLC
Numéro CAS: 71950-67-9
Pureté: >95%
Masse Moléculaire: 566.6
Formule Moléculaire: C31H34O10
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).
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Thielavin B is a potent Cox (prostaglandin, PG synthetase) inhibitor derived from Thielavia terricola. Studies show that Thielavins B inhibits PLC (Phospholipase C) as well as the synthesis of prostaglandin E2 from enoperoxides. Thielavins A (sc-202361) and B are composed of three hydroxybenzoic acid groups and are structurally related to depsides. Thielavins B has been shown to inhibit G6Pase in hepatic studies and inhibit the formation of peptidoglycan in the cell wall of Enterococcus. Additionally, the compound has been described to act as a telomerase inhibitor.


Références

1. Kitahara, N., et al. 1981. J. Antibiot. 34: 1562-1568. PMID: 7333968
2. Kitahara, N., et al. 1983. J. Antibiot. 36: 599-600. PMID: 6409872
3. Mani, N., et al. 1998. J. Antibiot. 51: 471-479. PMID: 9666175
4. Togashi, K., et al. 2001. Biosci. Biotechnol. Biochem. 65: 651-653. PMID: 11330682
5. Sakemi, S., et al. 2002. J. Antibiot. 55: 941-951. PMID: 12546415

Apparence :
Powder
État Physique :
Solid
Dérivé de :
Unidentified fungus
Solubilité :
Soluble in methanol, and DMSO.
STOCKAGE :
Store at 4° C
Point d'Ébullition :
807.54° C at 760 mmHg (Predicted)
Densité :
1.28 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.60 (Predicted)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
PubChem CID :
Numéro MDL :
MFCD11111623
SMILES :
CC1=CC(=C(C(=C1C(=O)OC2=C(C(=C(C(=C2C)OC)C(=O)OC3=C(C(=C(C(=C3C)OC)C(=O)O)C)C)C)C)O)C)O

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CERTIFICAT D'ANALYSE

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