Anticorps TFII-I (42): sc-136099
- L'anticorps TFII-I 42 est un monoclonal IgG1 de souris fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 17-123 de TFII-I d'origine human
- recommandé pour la détection de TFII-I d'origine mouse, rat, human et canine par WB, IP et IF
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire TFII-I (42). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
Initiation of transcription of eukaryotic genes requires the association of large multimeric protein complexes that involve RNA polymerase II and a variety of basal transcription factors, including members of the TFII protein family. TFII proteins complex with Pol II and initiate transcription by binding to the core promoter elements, such as TATA box sequences, that are located upstream of the transcription start codon. A member of the TFII family, TFII-I is regulated by tyrosine phophorylation, and it is involved in the initiation of transcription of TATA-less promoters and in cell type specific transcription. TFII-I directly associates with several promoters elements, including TATA box, pyrimidine-rich initiator (Inr) and E-box elements. TFII-I is also implicated in activating transcription of the transcription factor c-fos, a downstream effector protein in the MAP kinase-signaling pathway. TFII-I binds to several initiation sites within the c-fos promoter, and it is phosphorylated in response to Map kinase activation, which then enhances TFII-I induced expression of c-fos.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TFII-I (42) | sc-136099 | 50 µg/0.5 ml | $316.00 |