TBL1 Antibody (H-3): sc-137006
- TBL1 Antibody (H-3) is a mouse monoclonal IgG1 κ TBL1 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 211-577 of TBL1X of human origin
- TBL1 Antibody (H-3) is recommended for detection of TBL1X of mouse, rat and human origin and TBL1Y of human origin by WB, IP, IF and ELISA
- Anti-TBL1 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-137006 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TBL1 Antibody (H-3) for WB applications. This reagent is now offered in a bundle with TBL1 Antibody (H-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TBL1 Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-TBL1 antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBL1, or transducin β-like 1, plays a critical role in gene expression regulation by participating in ubiquitin/19S proteasome complex recruitment to nuclear receptor-regulated transcription units, essential for misfolded protein degradation and various cellular processes. TBL1 features six distinct β-transducin repeats, also known as WD40 repeats, which enable protein-protein interactions and multiprotein complex assembly. TBL1X, a TBL1 variant, functions within the N-CoR repressor complex and interacts with histones H2B, H3a, and H4, highlighting TBL1X′s role in chromatin remodeling and transcriptional repression. TBL1X defects have been linked to ocular albinism with late-onset sensorineural deafness, demonstrating TBL1X′s significance in human health. TBL1Y, the Y-linked counterpart, primarily expresses in fetal brain and prostate tissues, showcasing TBL1 proteins′ diverse roles in cellular function and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBL1 Antibody (H-3) References:
- X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. | Bassi, MT., et al. 1999. Am J Hum Genet. 64: 1604-16. PMID: 10330347
- A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. | Guenther, MG., et al. 2000. Genes Dev. 14: 1048-57. PMID: 10809664
- Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. | Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. | Skaletsky, H., et al. 2003. Nature. 423: 825-37. PMID: 12815422
- A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. | Perissi, V., et al. 2004. Cell. 116: 511-26. PMID: 14980219
- Reading and function of a histone code involved in targeting corepressor complexes for repression. | Yoon, HG., et al. 2005. Mol Cell Biol. 25: 324-35. PMID: 15601853
- Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness. | Yan, HT., et al. 2005. J Hum Genet. 50: 175-181. PMID: 15834507
- Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes. | Disteche, CM., et al. 1998. Mamm Genome. 9: 1062-4. PMID: 9880679
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBL1 Antibody (H-3) | sc-137006 | 200 µg/ml | $322.00 | |||
TBL1 Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-521391 | 200 µg Ab, 40 µg BP | $361.00 | |||
TBL1 Antibody (H-3) X | sc-137006 X | 200 µg/0.1 ml | $322.00 | |||
TBL1 Antibody (H-3) AC | sc-137006 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBL1 Antibody (H-3) HRP | sc-137006 HRP | 200 µg/ml | $322.00 | |||
TBL1 Antibody (H-3) FITC | sc-137006 FITC | 200 µg/ml | $336.00 | |||
TBL1 Antibody (H-3) PE | sc-137006 PE | 200 µg/ml | $349.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 488 | sc-137006 AF488 | 200 µg/ml | $364.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 546 | sc-137006 AF546 | 200 µg/ml | $364.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 594 | sc-137006 AF594 | 200 µg/ml | $364.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 647 | sc-137006 AF647 | 200 µg/ml | $364.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 680 | sc-137006 AF680 | 200 µg/ml | $364.00 | |||
TBL1 Antibody (H-3) Alexa Fluor® 790 | sc-137006 AF790 | 200 µg/ml | $364.00 |