ACCÈS RAPIDE AUX LIENS
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Tara (Trio-associated repeat on actin), also known as TRIOBP (TRIO and F-actin-binding protein) or DFNB28, is a widely expressed protein with highest levels of expression in heart and placenta. Tara localizes to the nucleus and cytoplasm. It contains a pleckstrin homology domain at the N-terminus and a coiled-coil region at the C-terminus. Tara binds to and interacts with Trio, TRF1 and F-actin. Via these interactions, Tara plays a role in the development of neural tissue and the organization of the actin cytoskeleton. Tara functions to stabilize F-actin structures and therefore is also involved in the control of cell growth and motility. Mutations in the gene encoding this protein may result in autosomal recessive nonsyndromic sensorineural deafness type 28 (DFNB28). Five isoforms exist for Tara due to alternative splicing. Isoform 3, also known as the long isoform, is exclusively expressed in fetal retina, cochlea and brain.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Tara (2438C1a) | sc-81128 | 100 µg/ml | $333.00 |