ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators. SYT-SSX chimeras are detected in most synovial sarcomas. Synovial sarcomas are responsible for up to 10% of soft tissue sarcomas and are histologically characterized as either biphasic or monophasic. Genetic analysis indicates that biphasic synovial sarcomas contain SYT-SSX1 fusions, whereas SYT-SSX2 fusions are found in monophasic synovial sarcomas, providing additional distinguishing characterization of these subtypes.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SYT (C-3) | sc-390266 | 200 µg/ml | $316.00 | |||
SYT (C-3): m-IgGκ BP-HRP Kit | sc-535608 | 200 µg Ab; 40 µg BP | $354.00 | |||
SYT (C-3): m-IgG2b BP-HRP Kit | sc-549456 | 200 µg Ab; 10 µg BP | $354.00 | |||
SYT (C-3) peptide neutralisant | sc-390266 P | 100 µg/0.5 ml | $68.00 | |||
Anticorps SYT (C-3) X | sc-390266 X | 200 µg/0.1 ml | $316.00 |