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Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Suppressin (A-7) | sc-376477 | 200 µg/ml | $316.00 | |||
Suppressin (A-7): m-IgG Fc BP-HRP Kit | sc-540578 | 200 µg Ab; 10 µg BP | $354.00 | |||
Suppressin (A-7): m-IgG1 BP-HRP Kit | sc-542218 | 200 µg Ab; 20 µg BP | $354.00 | |||
Suppressin (A-7) peptide neutralisant | sc-376477 P | 100 µg/0.5 ml | $68.00 |