Anticorps Staphylococcus aureus TSST-1 (7917): sc-58197

Staphylococcus aureus is a Gram-positive coccus that frequently lives on the skin or in the nose of humans. This microbe produces β-lactamase, enzymes which break down the β-lactam ring of the penicillin molecule, making it resistant to most penicillin and cephalosporins. Staphylococcus aureus causes a broad range of illnesses, from minor skin infections and abscesses to life-threatening diseases such as pneumonia, meningitis, endocarditis, septicemia and Toxic Shock Syndrome (TSS). Toxic Shock Syndrome Toxin-1 (TSST-1) is a staphylococcal secreted exotoxin that is responsible for TSS, since it leads to non-specific binding of MHC II with T cell receptors, resulting in polyclonal T cell activation. TSST-1 also plays a role in the pathogenesis of several autoimmune and allergic diseases associated with B cell hyperactivity, and it produces antagonistic effects on IL-4-induced IgE synthesis. Symptoms of TSS include high fever, accompanied by low blood pressure, malaise and confusion, which can rapidly progress to stupor, coma and multi-organ failure.