Anticorps SPIN90 (B-3): sc-377405

SPIN90 (also known as NCK-interacting protein with SH3 domain, diaphanous protein-interacting protein, DIP-1) is a 722 amino acid protein encoded by the human gene SPIN90. SPIN90 is a nuclear protein containing an SH3 domain, a proline-rich domain and a bipartite nuclear localization signal. The SH3 domain of SPIN90 has high homology with that of FYN. SPIN90 plays an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) and can induce microspike formation in vivo. SPIN90 facilitates the assembly of myofibrils into sarcomeres and mediates the maintenance of these sarcomeres. It is also believed to regulate Actin polymerization and cell adhesion. A chromosomal aberration involving SPIN90/AF3p21 is found in therapy-related leukemia involving a translocation at t(3;11)(p21;q23) with MLL. This occurs when intron 6 of the mixed lineage leukemia (MLL) gene is fused at a point upstream of exon 1 in the AF3p21 gene and the chromosome forms an MLL-AF3p21 fusion transcript in leukemic cells. The MLL gene is frequently rearranged in leukemia, especially in infantile leukemia and therapy-related leukemia. The MLL gene is localized at chromosome 11q23, and is involved in almost all of the chromosomal translocations involving 11q23.

L'anticorps SPIN90 préféré est l'Anticorps SPIN90 (B-6): sc-514232.