ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The SPA-1 (signal-induced proliferation-associated gene-1) protein is a principal RAP1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells. The SPA-1 gene is normally expressed in fetal and adult lymphohematopoietic tissues. Various types of mitogenic stimulation increase SPA-1 mRNA expression in normal lymphocytes. SPA-1 disrupts LFA-1-ICAM1-mediated adhesive interactions and subsequent T cell-receptor triggering and IL-2 production, possibly through inhibition of RAP1. Mice that are deficient for the SPA-1 gene develop age-dependent progression of T cell immunodeficiency followed by a spectrum of late onset myeloproliferative disorders, mimicking human chronic myeloid leukemia. SPA-1 also directly binds to AQP2 and plays a role in regulating AQP2 trafficking to the apical membrane.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SPA-1 (E-6) | sc-166949 | 200 µg/ml | $316.00 | |||
SPA-1 (E-6): m-IgG Fc BP-HRP Kit | sc-537553 | 200 µg Ab; 10 µg BP | $354.00 | |||
SPA-1 (E-6): m-IgGκ BP-HRP Kit | sc-534851 | 200 µg Ab; 40 µg BP | $354.00 | |||
SPA-1 (E-6): m-IgG1 BP-HRP Kit | sc-545224 | 200 µg Ab; 20 µg BP | $354.00 | |||
SPA-1 (E-6) peptide neutralisant | sc-166949 P | 100 µg/0.5 ml | $68.00 |