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SMPDL3B (sphingomyelin phosphodiesterase, acid-like 3B), also known as ASMLPD or ASML3B (Acid sphingomyelinase-like phosphodiesterase 3B), is a 455 amino acid secreted protein belonging to the acid sphingomyelinase family. It is expressed in granulosa cells of the ovarian follicle and is a homolog of ASM (acid sphingomyelinase). ASM is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine playing an important role in apoptosis of germ cell lines. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease with a later onset.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SMPDL3B (B-1) | sc-376870 | 200 µg/ml | $316.00 | |||
SMPDL3B (B-1): m-IgGλ BP-HRP Kit | sc-523123 | 200 µg Ab, 40 µg BP | $354.00 |