Date published: 2025-9-7

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Anticorps SmcX (C-12): sc-365861

5.0(2)
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Fiches techniques
  • L'Anticorps SmcX (C-12) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
  • dirigé contre les acides aminés 1462-1560 situés au niveau C-terminus de SmcX d'origine human
  • recommandé pour la détection de SmcX d'origine human par WB, IP, IF et ELISA
  • Réactifs TransCruz pour une application en ChIP (sc-365861 X, 200 µg/0.1 ml)
  • 2b BP-HRP">m-IgG2b BP-HRP est le réactif de détection secondaire préféré pour l'anticorps SmcX (C-12) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps SmcX (C-12)(voir les informations relatives à la commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and α-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps SmcX (C-12)

    sc-365861
    200 µg/ml
    $316.00

    SmcX (C-12): m-IgG2b BP-HRP Kit

    sc-548563
    200 µg Ab; 10 µg BP
    $354.00

    Anticorps SmcX (C-12) X

    sc-365861 X
    200 µg/0.1 ml
    $316.00

    What is the recommended fixation method for immunofluorescence staining with SmcX (C-12): sc-365861 monoclonal antibody?

    Posée par: Dr Ninau Qelp
    Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
    Répondue par: Technical Support
    Date de publication: 2017-03-01
    • y_2025, m_8, d_28, h_5CST
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    Rated 5 de 5 de par Exceptional immunofluorescence nuclear andExceptional immunofluorescence nuclear and cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
    Date de publication: 2015-04-19
    Rated 5 de 5 de par Satisfactory Western Blot data of SmcX expressionSatisfactory Western Blot data of SmcX expression in non-transfected and human SmcX transfected 293T whole cell lysates. -SCBT QC
    Date de publication: 2013-10-17
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    Anticorps SmcX (C-12) est évalué 5.0 de 5 de 2.
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