SKIV2L Antibody (1E5): sc-517119

SKIV2L Antibody (1E5) is a mouse monoclonal IgG2a kappa light chain antibody that detects SKIV2L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SKIV2L antibody (1E5) is available as the non-conjugated form. SKIV2L, also known as superkiller viralicidic activity 2-like, helicase-like protein, DDX13, SKI2W, or SKIV2, is a crucial 1,246 amino acid nuclear protein that functions primarily as a helicase and possesses ATPase activity, which is essential for unwinding RNA and DNA during various cellular processes. This unwinding capability is particularly important in antiviral responses, as SKIV2L inhibits the translation of poly(A) deficient mRNA, thereby playing a significant role in cellular defense against viral infections. The gene encoding SKIV2L is located on human chromosome 6p21.33, a region associated with several genetic disorders, including porphyria cutanea tarda and Parkinson′s disease, highlighting SKIV2L′s potential implications in both health and disease. With specific reactivity to mouse, rat, and human samples, SKIV2L monoclonal antibody (1E5) serves as an invaluable tool for researchers investigating molecular mechanisms of viral resistance and broader functions of helicases in cellular biology.

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SKIV2L Antibody (1E5) References:

1. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.  |  Chen, CY., et al. 2001. Cell. 107: 451-64. PMID: 11719186
2. Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology.  |  Kondo, N., et al. 2009. Ophthalmology. 116: 1502-9. PMID: 19556007
3. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.  |  Kopplin, LJ., et al. 2010. Genes Immun. 11: 609-21. PMID: 20861866
4. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family.  |  Dangel, AW., et al. 1995. Nucleic Acids Res. 23: 2120-6. PMID: 7610041
5. Identification and characterization of a human cDNA homologous to yeast SKI2.  |  Lee, SG., et al. 1995. Genomics. 25: 660-6. PMID: 7759100
6. A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene.  |  Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
7. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).  |  Albertella, MR., et al. 1996. Genomics. 36: 240-51. PMID: 8812450

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SKIV2L Antibody (1E5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SKIV2L Antibody (1E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SKIV2L Antibody (1E5) Specifications

Alternate Product Name: SKIV2L

Product Clone Name: 1E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1125-1233

Epitope Target: SKIV2L

Epitope Species: human

Product Reactivity/Detection: SKIV2L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SKIV2L Antibody (1E5): N/A