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SH2-B, also known as SH2B1 or PSM, is a 756 amino acid protein that is a component of the signaling network and is involved in the regulation of cell shape and movement. SH2-B is related to the APS (adapter molecule containing PH and SH2 domains) family of adapter proteins, which characteristically contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. SH2-B is alternatively spliced to generate three distinct isoforms, SH2-B α, β, and γ, that share an identical N-terminal sequence, including the PH domain, the SH2 domain, and multiple proline-rich motifs. Containing a PH domain and a SH2 domain, SH2-B shuttles between the nucleus and the cytoplasm. SH2-B is widely expressed with highest expression in skeletal muscle and ovary. SH2-B is phosphorylated on tyrosine residues in response to receptor kinase stimulation.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SH2-B α/β/γ/δ (46) | sc-136065 | 50 µg/0.5 ml | $316.00 |