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VOIR ÉGALEMENT...
SERGEF (secretion-regulating guanine nucleotide exchange factor), also called DelGEF (deafness locus-associated putative guanine nucleotide exchange factor), is a guanine nucleotide exchange factor which is thought to be involved in secretion pathways. SERGEF associates with Sec5, a protein required for secretion, in a magnesium-dependent manner and is stimulated by the presence of deoxycytidine triphosphate (dCTP) or guanosine triphosphate (GTP). A homolog of RanGEF, SERGEF is localized to the nucleus and cytoplasm and is expressed throughout the body with high expression observed in the brain, placenta and skeletal muscle. SERGEF is a 458 amino acid protein which, upon DNA damage, is phosphorylated by Atm or ATR. Two isoforms exist due to alternative splicing.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SERGEF (2261C3a) | sc-81078 | 100 µg/ml | $333.00 |