Anticorps SDF-1/CXCL12 (P-159X): sc-74271
- L'Anticorps SDF-1/CXCL12 (P-159X) est un monoclonal de souris IgG1 κ, cité dans 27 publications, fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 20-89 de SDF-1 d'origine human
- recommandé pour la détection de SDF-1α and SDF-1β d'origine mouse, rat et human par WB, IF et IHC(P)
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire SDF-1/CXCL12 (P-159X). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The C-X-C or α chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell-derived factor-1, or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven- pass, transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (also designated LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major co-receptor for T-tropic HIV-1, and SDF-1 has been shown to inhibit HIV-1 infection. Six human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1. Three isoforms are known for mouse and rat.
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Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SDF-1/CXCL12 (P-159X) | sc-74271 | 50 µg/0.5 ml | $316.00 |