Anticorps SARS NC (3851): sc-58192

Severe acute respiratory syndrome (SARS) coronavirus, a recently emergent infectious agent, shares little homology with previously known coronaviruses with respect to its genes and encoding proteins. Following this pattern, SARS nucleocapsid protein (SARS NC) only weakly resembles analogous proteins of the coronavirus family, and thus estimations of its function prove difficult. In fact, the region encoding SARS NC and other matrix and nucleocapsid proteins more closely resembles avian coronaviruses, while phylogenetic analyses indicate a mammalian origin for the replicase protein. SARS NC expression increases the binding of transcription factors to promotor sequences of c-Fos, ATF2, CREB-1, and FosB, all components of the AP-1 signaling pathway. Other signaling pathways, e.g. the NFκB pathway, are not affected, however, implying that pathway activation by SARS NC is selective, and thus possibly an important target in SARS functional studies.