Molecular structure of S-Methyl-L thiocitrulline, Dihydrochloride, CAS Number: 209589-59-3
S-Methyl-L thiocitrulline, Dihydrochloride (CAS 209589-59-3)
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Application:
S-Methyl-L thiocitrulline, Dihydrochloride is a potent inhibitor of NOS1 and NOS3
CAS Number:
209589-59-3
Molecular Weight:
278.2
Molecular Formula:
C7H15N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-Methyl-L thiocitrulline Dihydrochloride is a potent cell-permeable inhibitor of NOS1 (nNOS) (IC50 = 300 nM), and a fairly potent inhibitor of NOS3 (eNOS) (IC50 = 5.4 μM). S-Methyl-L thiocitrulline has been shown to provide neuroprotection in mice, thought to be accomplished by blocking NO generation, which could otherwise combine with free radicals producing tissue damaging peroxynitrites.
S-Methyl-L thiocitrulline, Dihydrochloride (CAS 209589-59-3) References
- Vagal ganglionic and nonadrenergic noncholinergic neurotransmission to the ferret lower oesophageal sphincter. | Smid, SD. and Blackshaw, LA. 2000. Auton Neurosci. 86: 30-6. PMID: 11269922
- A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain. | Colado, MI., et al. 2001. Br J Pharmacol. 134: 1711-23. PMID: 11739248
- Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. | Darvesh, AS., et al. 2005. J Pharmacol Exp Ther. 312: 694-701. PMID: 15456837
- NO news is not necessarily good news in cancer. | Ekmekcioglu, S., et al. 2005. Curr Cancer Drug Targets. 5: 103-15. PMID: 15810875
- Effect of S-methyl-l-thiocitrulline dihydrochloride on rat micturition reflex. | Rocha, JN. 2016. Int Braz J Urol. 42: 1018-1027. PMID: 24893916
- The neuronal NOS inhibitor L-MIN, but not 7-NINA, reduces neurotoxic effects of chronic intrastriatal administration of quinolinic acid. | Bazzett, T., et al. 1997. Brain Res. 775: 229-32. PMID: 9439850
Inhibitor of:
NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Methyl-L thiocitrulline, Dihydrochloride, 10 mg | sc-3571 | 10 mg | $56.00 |