ACCÈS RAPIDE AUX LIENS
RP2 (retinitis pigmentosa 2), also known as TBCCD2, is a 350 amino acid protein that localizes to the cytoplasmic side of the cell membrane and belongs to the TBCC family. Expressed ubiquitously, RP2 functions to stimulate the GTPase activity of tubulin and is thought to act as a guanine nucleotide dissociation inhibitor for ARL3 (ADP-ribosylation factor-like 3), preventing the GTP-bound form of ARL3 from dissociating. Via its ability to stimulate tubulin activity, RP2 plays an important role in retinal development. RP2 contains one C-CAP/cofactor C-like domain and can be myristoylated or palmitoylated, both of which are thought to be required for proper membrane targeting. Defects in the gene encoding RP2 are the cause of retinitis pigmentosa type 2 (RP2), a disorder characterized by the degeneration of photoreceptor cells, resulting in night vision blindness and an eventual loss of both peripheral and central vision.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RP2 (37.28) | sc-81892 | 100 µg/ml | $333.00 |