The vision system comprises a cascade of complex biochemical reactions that each contain numerous steps taking place in a matter of nanoseconds. RGS represents a family of GTPase accelerating proteins (GAPs) which play important roles in the vision system pathways. RGS9 is a member of this family and is the main source of GAP activity in the rod outer segments. RGS9-1 is an isoform of RGS9 that is found predominately in vertebrate cone and rod photoreceptors, and is required for rapid recovery of the light response in these locations. RGS9-1 is a peripheral protein of the disk membranes that binds membranes very tightly. R9AP binds to the N-terminal domain of RGS9-1 and anchors it to the disk membrane through a C-terminal transmembrane helix. RGS9-1 is phosphorylated by protein kinase A in a mechanism that may be responsible for mediating a stronger photoresponse in dark-adapted cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RGS9-1 (D3) | sc-53988 | 200 µg/ml | $316.00 |