Regulators of G-protein signaling (RGS proteins) are a family of highly diverse, multifunctional signaling proteins that share a conserved 120 amino acid domain (RGS domain). RGS domains bind directly to activated Ga subunits and act as GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both Ga-GTP and Gbg. RGS proteins shorten the lifetime of the activated G protein. RGS16 is expressed at high levels in retina. Overexpression of RGS16 inhibits G protein-coupled mitogenic signal transduction and activation of the mitogen-activated protein kinase (MAPK) signaling cascade. Rgs16 enhances the rate of GTP-hydrolysis by transducin, suggesting that Rgs16 may play a role in regulating the kinetics of signaling in the phototransduction cascade. The gene which encodes RGS16 maps to human chromosome 1q25-q31.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RGS16 (F-9) | sc-398120 | 200 µg/ml | $316.00 | |||
RGS16 (F-9): m-IgG Fc BP-HRP Kit | sc-538369 | 200 µg Ab; 10 µg BP | $354.00 | |||
RGS16 (F-9): m-IgGκ BP-HRP Kit | sc-535970 | 200 µg Ab; 40 µg BP | $354.00 | |||
RGS16 (F-9): m-IgG2a BP-HRP Kit | sc-548280 | 200 µg Ab; 10 µg BP | $354.00 | |||
RGS16 (F-9) peptide neutralisant | sc-398120 P | 100 µg/0.5 ml | $68.00 |