Anticorps Rent3 (C-2): sc-398820
- L'Anticorps Rent3 (C-2) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 51-240 situés près de la région N-terminus de Rent3b d'origine human
- recommandé pour la détection de Rent3a and Rent3b d'origine mouse, rat et human par WB, IP, IF et ELISA; également réactif avec d'autres espèces, dont bovine
- Réactifs TransCruz pour une application en ChIP (sc-398820 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, 2a BP-HRP">m-IgG2a BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps Rent3 (C-2) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps Rent3 (C-2)(voir les informations de commande ci-dessous).
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability. Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase. Rent1 protein has nucleic-acid-dependent ATPase activity and 5' to 3' helicase activity. In addition, Rent1 is an RNA-binding protein whose activity is modulated by ATP and directly interacts with Rent2, which is a mammalian homolog of Upf2p. Two mammalian orthologs to Upf3p, Rent3a and Rent3b, are encoded by two separate genes. Rent3b (also known as Rent3X) is encoded by a X-linked gene and localizes primarily to the nucleus, while Rent 1 and Rent 2 localize primarily in the cytoplasm. Specific Rent3 protein interactions with Y14 and spliced mRNA suggest Rent3a and Rent3b serve as a link between splicing and NMD in the cytoplasm.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rent3 (C-2) | sc-398820 | 200 µg/ml | $316.00 | |||
Rent3 (C-2): m-IgG Fc BP-HRP Kit | sc-538528 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rent3 (C-2): m-IgGκ BP-HRP Kit | sc-536156 | 200 µg Ab; 40 µg BP | $354.00 | |||
Rent3 (C-2): m-IgG2a BP-HRP Kit | sc-548331 | 200 µg Ab; 10 µg BP | $354.00 | |||
Anticorps Rent3 (C-2) X | sc-398820 X | 200 µg/0.1 ml | $316.00 |