Rent1 Antibody (G-3): sc-166092

Rent1 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects Rent1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rent1, also known as the regulator of nonsense transcripts and HUpf1, plays a crucial role in the nonsense-mediated RNA decay (NMD) pathway, which maintains cellular integrity by preventing the translation of faulty transcripts that could lead to truncated or malfunctioning proteins. Rent1 is primarily located in the cytoplasm, where Rent1 interacts with other key components of the NMD machinery, such as Rent2, a mammalian homolog of Upf2p, and Rent3 proteins, which link splicing and NMD processes. Rent1′s cytoplasmic presence allows for timely degradation of defective mRNA, safeguarding the cell from potential damage caused by aberrant protein synthesis. Additionally, Rent1′s structure includes an N-terminal zinc finger-like domain and NTPase domains, which are essential for helicase activity, enabling RNA structure unwinding during the decay process. Anti-Rent1 antibody (G-3) is an invaluable tool for researchers studying RNA metabolism and gene expression regulation mechanisms.

The preferred Rent1 antibody is Rent1 Antibody (C-6): sc-393594.