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RAP1, also known as TERF2IP (telomeric repeat-binding factor 2-interacting protein 1) or DRIP5, is a 399 amino acid nuclear and cytoplasmic protein that contains one BRCT domain and one Myb-like domain. Belonging to the RAP1 family, RAP1 acts as both a regulator of telomere function and a regulator of transcription. While it does not bind DNA directly, RAP1 is recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TRF2. RAP1 is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. The gene that encodes RAP1 maps to human chromosome 16q23.1 and mouse chromosome 8 E1.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rap1 (A-8) | sc-166556 | 200 µg/ml | $316.00 | |||
Rap1 (A-8): m-IgG Fc BP-HRP Kit | sc-540121 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rap1 (A-8): m-IgG1 BP-HRP Kit | sc-541916 | 200 µg Ab; 20 µg BP | $354.00 |