Ral A and Ral B constitute a distinct subfamily of Ras-related GTPases (i.e., GDP/GTP binding proteins) (1-3). Ral proteins are activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein. Unlike Ras proteins, Ral A and Ral B fail to induce transformed foci when activated variants are expressed in various recipient cells. A potential downstream target of Ral, designated Ral BP-1, has been shown to contain a Rho-GTPase-activating domain. This Rho-GTPase-activating domain interacts preferentially with the Rho family member Cdc42. A Ras/Ral signaling pathway has been reported to mediate phospholipase D (PLD) activation by v-Src, thus indicating PLD as another downstream target of Ral A.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Ral A/B (F-2) | sc-373998 | 200 µg/ml | $316.00 | |||
Ral A/B (F-2): m-IgG Fc BP-HRP Kit | sc-537900 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ral A/B (F-2): m-IgGκ BP-HRP Kit | sc-535363 | 200 µg Ab; 40 µg BP | $354.00 | |||
Ral A/B (F-2): m-IgG1 BP-HRP Kit | sc-545436 | 200 µg Ab; 20 µg BP | $354.00 |