Anticorps Rad51B (F-12): sc-377192
- L'Anticorps Rad51B (F-12) est un monoclonal de souris IgG1 κ, cité dans 5 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 141-255 dans une région interne de Rad51B d'origine human
- recommandé pour la détection de Rad51B d'origine human par WB, IP, IF et ELISA
- Réactifs TransCruz pour une application en ChIP (sc-377192 X, 200 µg/0.1 ml)
- 1 BP-HRP">m-IgG1 BP-HRP est le réactif de détection secondaire préféré pour l'anticorps Rad51B (F-12) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps Rad51B (F-12)(voir les informations relatives à la commande ci-dessous).
Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54, MRE11) mediate DNA double-strand break repair (DSBR) for DNA damage that otherwise could cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single-stranded DNA ends and catalyzes DNA-DNA interaction necessary for the annealing of complementary strands. Rad52 can interact with Rad51. Rad54A of the DEAD-like helicase superfamily binds to double-strand DNA and induces a DNA topological change, which is thought to facilitate homologous DNA pairing and stimulate DNA recombination. Rad54B of the DEAD-like helicase superfamily binds to double-stranded DNA and displays ATPase activity in the presence of DNA. Rad54B is abundant in testis and spleen, and mutations of this gene occur in primary lymphoma and colon cancer. MRE11 (meiotic recombination 11, ATLD, HNGS1) is a nuclear 3'-5' exonuclease/endonuclease that associates with Rad50 and influences homologous recombination, telomere length maintenance, and DNA double-strand break repair. MRE11 is most abundant in proliferating tissues.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rad51B (F-12) | sc-377192 | 200 µg/ml | $316.00 | |||
Rad51B (F-12): m-IgG1 BP-HRP Kit | sc-542707 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps Rad51B (F-12) X | sc-377192 X | 200 µg/0.1 ml | $316.00 |