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Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPα, PTPβ, PTPγ, PTPδ, PTPe, PTPΩ, PTPκ and PTPµ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPMT1 (protein tyrosine phosphatase mitochondrial 1), also known as MOSP or PLIP (phosphoinositide lipid phosphatase) and previously known as DUSP23, is a widely expressed PTP membrane protein with high expression levels in pancreatic β cells. PTPMT1 exclusively localizes to the matrix face of the inner membrane of the mitochondrion. It is responsible for dephosphorylating mitochondrial proteins and therefore plays a significant role in the production of ATP and secretion of insulin. For its substrate, PTPMT1 displays a specific preference for the lipid signaling molecule, phosphatidylinositol 5-phosphate (PI(5)P).
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PTPMT1 (B-12) | sc-390947 | 200 µg/ml | $316.00 | |||
PTPMT1 (B-12): m-IgGκ BP-HRP Kit | sc-535666 | 200 µg Ab; 40 µg BP | $354.00 | |||
PTPMT1 (B-12): m-IgG2a BP-HRP Kit | sc-546229 | 200 µg Ab; 10 µg BP | $354.00 |