Anticorps PTP IA-2 (98/4H6): sc-130570
- L'Anticorps PTP IA-2 (98/4H6) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre le domaine cytoplasmique correspondant aux acides aminés 602-979 de PTP IA-2 d'origine human.
- recommandé pour la détection de amino acids 618-628 of PTP IA-2 d'origine mouse, rat et human par WB, IP, IF et IHC(P)
- m-IgG1 BP-HRP est le réactif secondaire recommandé pour la détection de l'anticorps PTP IA-2 (98/4H6) pour des applications de WB and IHC(P). Ce réactif est maintenant proposé en kit avec l'anticorps PTP IA-2 (98/4H6) (voir Informations pour la commande ci-dessous).
Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPα, PTPβ, PTPγ, PTPδ, PTPe, PTPΩ, PTPκ and PTPµ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain, and an extracellular N-terminus. Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis. PTP IA-2 is an autoantigen and contributes to insulin-dependent diabetes mellitus (IDDM). The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PTP IA-2 (98/4H6) | sc-130570 | 200 µg/ml | $316.00 | |||
PTP IA-2 (98/4H6): m-IgG1 BP-HRP Kit | sc-542637 | 200 µg Ab; 20 µg BP | $354.00 |