PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) is a synthetic derivative of phosphatidylinositol trisphosphate (PIP3), a key signaling lipid involved in various cellular processes, particularly in the regulation of intracellular signaling pathways. This chemical is commonly used in research to investigate the role of PIP3 in cell signaling cascades, including those mediated by phosphoinositide 3-kinases (PI3Ks) and protein kinase B (Akt). Mechanistically, PIP3 serves as a second messenger by recruiting and activating downstream effector proteins containing pleckstrin homology (PH) domains to cellular membranes, leading to the initiation of diverse cellular responses such as cell proliferation, survival, and metabolism. In experimental settings, researchers utilize PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) to modulate PIP3 levels in cells and dissect its specific contributions to various physiological and pathological processes. Techniques such as lipidomics, fluorescence microscopy, and biochemical assays are employed to elucidate the precise mechanisms of PIP3-mediated signaling and its implications in cellular function and disease states, offering valuable insights into potential strategies targeting dysregulated PI3K/Akt signaling pathways.