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Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37% of normal) correlates with severe recurrent venous thrombosis.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Protein S (C-5) | sc-271400 | 200 µg/ml | $316.00 | |||
Protein S (C-5): m-IgGκ BP-HRP Kit | sc-534949 | 200 µg Ab; 40 µg BP | $354.00 | |||
Protein S (C-5): m-IgG2a BP-HRP Kit | sc-546201 | 200 µg Ab; 10 µg BP | $354.00 |