Prostaglandin E2-biotinamide CAS: 363-24-6 (unconjugated)
MF: C35H58N4O6S
MW: 662.9
A biotinylated PGE2 derivative designed to detect PGE2 bound in complexes.

Prostaglandin E2-biotinamide (CAS 363-24-6 (unconjugated))

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Application: Prostaglandin E2-biotinamide is A biotinylated PGE2 derivative designed to detect PGE2 bound in complexes
Numéro CAS: 363-24-6 (unconjugated)
Masse Moléculaire: 662.9
Formule Moléculaire: C35H58N4O6S
Information supplémentaire: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).

Prostaglandin E2-biotinamide is a biotinylated Prostaglandin E2 (PGE2; sc-201225) derivative that is designed to allow PGE2 to be detected in complexes with transmembrane receptors and/or nucleic acid or protein binding partners - an incredibly useful tool in the general elucidation of the mechanism of action of Prostaglandins. PGE2 is the most physiologically abundant eicosanoid, which is produced predominantly from arachidonic acid (sc-200770) by COX and PGES, and exists at some level in nearly all cell types. PGE2 acts on four different receptors termed EP1 through EP4 yielding an astounding array of biological effects; including: potent vasodialation, smooth muscle relaxation, both anti- and proinflammatory activities, stimulates bone resorption, synergizes with LTB4, facilitates replication of AIDS virus, regulates sleep/wake cycle, demonstrates thermoregulatory action in the CNS, induces LHRH release from rat median eminence, demonstrates a protective effect on gastric mucosa, and regulates renal hemodynamics and sodium excretion.


Références

1. Richardson, P.D., et al. 1976. Br. J. Pharmacol. 57: 581-588. PMID: 963344
2. Raisz, L.G., et al. 1977. Nature. 267: 532-534. PMID: 876371
3. Miller, T.A., 1983. Am. J. Physiol. 245: G601-G623. PMID: 6195926
4. Kuno, S., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 3487-3490. PMID: 3010301
5. Kuno, S., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 2682-2683. PMID: 3458226
6. Archer, C.B., et al. 1987. Prostaglandins. 33: 799-805. PMID: 2823313
7. Hayaishi, O. 1988. J. Biol. Chem. 263: 14593-14596. PMID: 3049580
8. Raud, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 2315-2319. PMID: 2451246
9. Long, C.R., et al. 1990. Prostaglandins. 40: 591-601. PMID: 2093936
10. Christman, J.W., et al. 1991. Prostaglandins. 41: 251-262. PMID: 1852897
11. Gerozissis, K., et al. 1991. Prostaglandins. 41: 345-357. PMID: 1871376

Formulation :
A solution in ethanol
État Physique :
Liquid
STOCKAGE :
Store at -20° C
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
Transport :
UN 1170, Class 3, Packing group II
SMILES :
CCCCCC(O) /C=C/[[email protected]] 1C(O) CC(=O) C1C/C=C\CCCC(=O) NCCCCCNC(=O) CCCCC1SCC2NC(=O) NC12

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