Molecular structure of PP 1, CAS Number: 172889-26-8
PP 1 (CAS 172889-26-8)
See product citations (6)
Alternate Names:
1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine
Application:
PP 1 is a selective and potent Src family tyrosine kinase inhibitor
CAS Number:
172889-26-8
Purity:
≥98%
Molecular Weight:
281.36
Molecular Formula:
C16H19N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PP 1 is a selective and potent Src family tyrosine kinase inhibitor. PP 1 studies have proved its ability to potently inhibit Lck and Fyn (FynT), IL-2 gene activation in T lymphocytes, and anti-CD3-induced protein tyrosine phosphorylation. Research indicates that PP 1 effectively blocks LPA and EGF-enhanced tyrosine phosphorylation, MAPK activation downstream of EGFR, Rsk-1 (p90RSK) activation by H2O2, Kit and Bcr-Abl tyrosine kinases, and degrades RETMEN2A and RETMEN2B oncoproteins via proteosomal targeting. Rat basophilic leukemia cell studies have shown that PP 1 inhibits Fc epsilonRI- and Thy-1-mediated activation. Structural studies have revealed that PP 1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases.
PP 1 (CAS 172889-26-8) References
- Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. | Osterhout, DJ., et al. 1999. J Cell Biol. 145: 1209-18. PMID: 10366594
- Structural basis for selective inhibition of Src family kinases by PP1. | Liu, Y., et al. 1999. Chem Biol. 6: 671-8. PMID: 10467133
- Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras. | Abe, J., et al. 2000. J Biol Chem. 275: 1739-48. PMID: 10636870
- The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. | Tatton, L., et al. 2003. J Biol Chem. 278: 4847-53. PMID: 12475982
- The specificities of protein kinase inhibitors: an update. | Bain, J., et al. 2003. Biochem J. 371: 199-204. PMID: 12534346
- PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting. | Carniti, C., et al. 2003. Cancer Res. 63: 2234-43. PMID: 12727845
- Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling. | Wittköpper, K., et al. 2011. Cardiovasc Res. 91: 392-401. PMID: 21354993
- Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. | Hanke, JH., et al. 1996. J Biol Chem. 271: 695-701. PMID: 8557675
- Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. | Kwon, YG., et al. 1997. Proc Natl Acad Sci U S A. 94: 3536-41. PMID: 9108011
- Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells. | Amoui, M., et al. 1997. Eur J Immunol. 27: 1881-6. PMID: 9295022
- Signal characteristics of G protein-transactivated EGF receptor. | Daub, H., et al. 1997. EMBO J. 16: 7032-44. PMID: 9384582
- Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. | Igishi, T. and Gutkind, JS. 1998. Biochem Biophys Res Commun. 244: 5-10. PMID: 9514877
- The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. | Tang, H., et al. 1998. J Biol Chem. 273: 18268-72. PMID: 9660790
Inhibitor of:
1190028D05Rik, 1700008F21Rik, 1700019A02Rik, 3BP1, 5830404H04Rik, 6430706D22Rik, A430084P05Rik, A930008G19Rik, ABHD4, AFAP-1L1, AHNAK2, AI449175, AU019823, BC016579, c-Src, C1orf113, C1orf185, CNIH2, Crk-L, Csk, Fyn, GRB14, JIK, Lck, MAIR-II, MOB3A, NEPH1, NRK, p140Cap, PDLIM5, QIP1, SH3PXD2B, SKAP55, Slp5, STS-1, TorsinB, and Tyrosine Kinase.Activator of:
ARAP2, ARHGAP22, c-Src, C130050O18Rik, CD9, FRP-2, Fyn, group III sPLA2, Integrin β3, PID1, TCR δ, and Trav3d-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP 1, 1 mg | sc-203212 | 1 mg | $86.00 | |||
PP 1, 5 mg | sc-203212A | 5 mg | $145.00 |