Date published: 2025-9-8

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Anticorps POSH (A-4): sc-376059

5.0(1)
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Fiches techniques
  • L'Anticorps POSH (A-4) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
  • dirigé contre les acides aminés 591-880 situés près de la région C-terminal de POSH d'origine mouse
  • recommandé pour la détection de POSH d'origine mouse, rat et human par WB, IP, IF et ELISA
  • m-IgG Fc BP-HRP et 1 BP-HRP">m-IgG1 BP-HRP sont les réactifs de détection secondaire préférés pour POSH Antibody (A-4) for WB applications. Ces réactifs sont désormais proposés en lots avec POSH Antibody (A-4)(voir les informations de commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    Rho, Rac and Cdc42 are members of the small GTPase family. These proteins act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. Activation of these proteins results in rearrangements of filamentous actin and the formation of actin stress fibers. Many of the targets of these GTPases are involved in signal transduction events mediated by Src homology 3 (SH3) domains. POSH, for "plenty of SH3s", is a Rac binding protein with four SH3 domains. POSH preferentially interacts with the GTP form of RAC and not with the GDP-bound RAC. Ectopic expression of POSH elicits JNK activation and nuclear translocation of NFkB, suggesting that POSH is involved in Rac regulation of these kinase pathways. Overexpression of POSH has also been shown to induce apoptosis.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps POSH (A-4)

    sc-376059
    200 µg/ml
    $316.00

    POSH (A-4): m-IgG Fc BP-HRP Kit

    sc-540503
    200 µg Ab; 10 µg BP
    $354.00

    POSH (A-4): m-IgG1 BP-HRP Kit

    sc-542164
    200 µg Ab; 20 µg BP
    $354.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with POSH (A-4): sc-376059 monoclonal antibody?

    Posée par: jerojero
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Répondue par: Technical Support
    Date de publication: 2017-02-27
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    Rated 5 de 5 de par Produced nice Western blot data of POSH expressionProduced nice Western blot data of POSH expression in KNRK whole cell lysate. -SCBT QC
    Date de publication: 2014-03-20
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    Anticorps POSH (A-4) est évalué 5.0 de 5 de 1.
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